Ready-to-use calibrants for extractables & leachables testing methods

M. Obkircher

Merck, Darmstadt, Germany

Al’manac of Modern Metrology № 1 (33) 2023, pages 159–161

Abstract: Packaging materials serve as the first line of defense to ensure the quality of their contents. Concerns have been raised in recent years about extractables and leachables affecting public health and safety, as some of these compounds have potentially toxic characteristics.
This paper presents the first two, ready-to-use, certified reference materials for chromatograph calibration. The components of these two mixtures are the most significant organic chemicals for the food and pharmaceutical market segments.

Keywords: certified reference material, packaging material, calibrant, liquid chromatography — mass spectrometry, gas chromatography — mass spectrometry.

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